Reaktion #45429

Reaktionsgleichung

solution

(4-amino-3-bromothieno[3,2-c]pyridin-7-yl)methanol

→

desired product

Ausbeute 89.0%

4-amino-3-bromothieno[3,2-c]pyridine-7-carbaldehyde

Ausbeute 89.0%

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationfiltered through diatomaceous earth (Celite®)
2. 2
   WaschenThe pad was washed with THF and dichloromethane
3. 3
   Einengenthe combined filtrates were concentrated

Vorschrift

A solution of Example 277E (1 g, 3.86 mmol) in THF (100 mL) was treated with MnO2 (2.66 g, 42.1 mmol), stirred overnight at room temperature, and filtered through diatomaceous earth (Celite®). The pad was washed with THF and dichloromethane and the combined filtrates were concentrated to provide 0.88 g (89% yield) of the desired product. MS (ESI(+)) m/e 256.8, 258.8 (M+H)+.

Quelle