Reaktion #4542

Reaktionsgleichung

3

2-Amino-6-chloro-3,5-pyridinedicarbonitrile

→

2-Amino-3,5-dicyanopyridine

Ausbeute 73.0%

Lösungsmittel

cyclohexane EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigedescribed below for the preparation of 5 except that 5
2. 2
   Sonstigewas recrystallised from MeCN [methyl cyanide

Vorschrift

2-Amino-3,5-dicyanopyridine (5) was prepared from 3 using the procedure described below for the preparation of 5 except that 5 was recrystallised from MeCN [methyl cyanide; acetonitrile) (instead of EtOH). The yield was 73% (7.00 g from 12.0 g (67.2 mmol) of 3] of product homogeneous on TLC (cyclohexane-EtOAc, 1:1); mp 220° C. dec; 1H NMR (Me2SO-d6) δ7.90 (s, NH2), 8.40 and 8.58 (two d, 4-H and 6H, J=2 Hz).

Quelle