Reaktion #4539

Reaktionsgleichung

hydrazine hydrate

3-cyano-5-dimethoxymethyl-2-phthalimidopyrazine

→

2-amino-3-cyano-5-dimethoxymethylpyrazine

Ausbeute 75.1%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONImmediately after the addition
2. 2
   Sonstigecrystals were precipitated after a few minutes

Vorschrift

0.2 g of hydrazine hydrate were added dropwise to a suspension of 2 g of 3-cyano-5-dimethoxymethyl-2-phthalimidopyrazine in 40 ml of absolute methanol at 40° C. Immediately after the addition, the solution became clear, and crystals were precipitated after a few minutes. Chromatography over silica gel gave 0.9 g (75%) of 2-amino-3-cyano-5-dimethoxymethylpyrazine. 1H-NMR (270 MHz, DMSO-d6): δ3.3 (s, 6H), 5.0 (s, 1H), 8.35 (s, 1H).

Quelle