Reaktion #45374

Reaktionsgleichung

2,4,6-Trichloropyridine

Methylamine

→

2,6-Dichloro-4-methylamino-pyridine

Lösungsmittel

ethanol

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Einengenconcentrated
2. 2
   FiltrationThe product was filtered
3. 3
   Waschenwashed with methyl t-butyl ether (1,500 ml)
4. 4
   Sonstigedried
5. 5
   Sonstigeto yield A1.6 (1200 g, 68%)

Vorschrift

2,4,6-Trichloropyridine (1800 g, 9.89 mol) was dissolved in ethanol (1800 mL). Methylamine 40% solution in ethanol (6.3 L) was added over 1 h and 40 min maintaining the reaction temperature between 20-25° C. The reaction was stirred for 14 hours at room temperature and concentrated. The product was filtered, washed with methyl t-butyl ether (1,500 ml) and dried to yield A1.6 (1200 g, 68%)

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