Reaktion #453627

Reaktionsgleichung

2-pyridin-2-yl-benzoxazol-6-ol

4-aminoresorcinol hydrochloride

nicotinyl chloride hydrochloride

pyridinium-p-toluenesulfonate

→

2-Pyridin-3-yl-benzoxazol-6-ol

Lösungsmittel

triethylamine

—

xylenes

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigem.p., 176-178° C.

Vorschrift

2-Pyridin-3-yl-benzoxazol-6-ol was prepared using 4-aminoresorcinol hydrochloride (1.5 g, 9.3 mM), nicotinyl chloride hydrochloride (1.8 g, 10.2 mM), triethylamine (3.0 g, 30.0 mM) and pyridinium-p-toluenesulfonate (PPTS, 800 mg, 3.2 mM) were refluxed in xylenes (50 mL) for about 24 hours as described for 2-pyridin-2-yl-benzoxazol-6-ol; m.p., 176-178° C.

Quelle