Reaktion #453096

Reaktionsgleichung

HCl

6-chloro-3-(1-methyl-2-(R)-azetidinylmethoxy)-5-phenylpyridine

hydrogen chloride

MeOH

→

6-Chloro-3-(1-methyl-2-(R)-azetidinylmethoxy)-5-phenylpyridine hydrochloride

Lösungsmittel

Et2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto afford the tittle compound

Vorschrift

To a solution of 6-chloro-3-(1-methyl-2-(R)-azetidinylmethoxy)-5-phenylpyridine in Et2O was added hydrogen chloride (1.0 M in Et2O) carefully to afford the tittle compound: mp 173-175° C.; 1H NMR (D2O) δ 2.60-2.78 (m, 3H), 3.00 (s, 3H), 4.02 (m, 1H), 4.25 (m, 1H), 4.60-4.78 (m, 2H), 7.56-7.60 (m, 6H), 8.18 (d, 1H, J=2.0 Hz); MS (CI/NH3) m/z 289 (M+H)+. Anal. Calcd for C16H17ClN2O.1.1 HCl; C, 58.43; H, 5.55; N, 8.52. Found: C, 58.37; H, 5.56; N, 8.43. [α]D23 +40.37 (c 0.27, MeOH).

Quelle