Reaktion #453093

Reaktionsgleichung

HCl

3-(2-(R)-azetidinylmethoxy)-6-chloro-5-phenyl-pyridine

hydrogen chloride

MeOH

→

3-(2-(R)-Azetidinylmethoxy)-6-chloro-5-phenylpyridine hydrochloride

Lösungsmittel

Et2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto afford the tittle compound

Vorschrift

To a solution of 3-(2-(R)-azetidinylmethoxy)-6-chloro-5-phenyl-pyridine in Et2O was added hydrogen chloride (1.0 M in Et2O) carefully to afford the tittle compound: mp 143-145° C.; 1H NMR (D2O) δ 2.70 (q, 2H, J=8.5 Hz), 4.02-4.22 (m, 2H), 4.46 (d, 2H, J=4.5 Hz), 4.97 (m, 1H), 7.57 (s, 5H), 7.60 (d, 1H, J=3.0 Hz), 8.19 (d, 1H, J=3.0 Hz); MS (CI/NH3) m/z 275 (M+H)+. Anal. Calcd for C15H15ClN2O.1.4 HCl: C, 55.30; H, 5.07; N, 8.60. Found: C, 55.19; H, 5.25; N, 8.52. [α]25D +9.4 (c 0.8, MeOH).

Quelle