Reaktion #453084

Reaktionsgleichung

HCl

MeOH

5-allyl-3-(1-methyl-2-(R)-pyrrolidinylmethoxy)pyridine

hydrogen chloride

H2O

→

5-Allyl-3-(2-(S)-azetidinylmethoxy)pyridine hydrochloride

Lösungsmittel

Et2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto afford the tittle compound

Vorschrift

To a solution of 5-allyl-3-(1-methyl-2-(R)-pyrrolidinylmethoxy)pyridine in Et2O was added hydrogen chloride (1.0 M in Et2O) carefully to afford the tittle compound: 1H NMR (D2O) δ 2.70 (q, 2H, J=8.5 Hz), 3.49 (d, 2H, J=6.5 Hz), 4.02-4.20 (m, 2H), 4.44 (d, 2H, J=4.5 Hz), 4.95 (m, 1H), 5.12-5.20 (m, 2H), 6.05 (m, 1H), 7.53 (s, 1H), 8.15 (s, 1H), 8.24 (d, 1H, J=2.0 Hz); MS (CI/NH3) m/z 205 (M+H)+. Anal. Calcd for C12H16N2O.2 HCl.0.2 H2O: C, 54.14; H, 6.82; N, 10.52. Found: C, 54.30; H, 6.82; N, 10.49. [α]25D -3.5 (c 0.63, MeOH).

Quelle