Reaktion #453074

Reaktionsgleichung

HCl

MeOH

3-(2-(S)-azetidinylmethoxy)-6-chloro-5-(5-pyrimidinyl)pyridine

hydrogen chloride

H2O

→

3-(2-(S)-Azetidinylmethoxy)-6-chloro-5-(5-pyrimidinyl)pyridine dihydrochloride

Lösungsmittel

Et2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto afford the tittle compound

Vorschrift

To a solution of 3-(2-(S)-azetidinylmethoxy)-6-chloro-5-(5-pyrimidinyl)pyridine from step c above in Et2O was added hydrogen chloride (1.0 M in Et2O) carefully to afford the tittle compound: mp 144° C. (dec.); 1H NMR (D2O) δ 2.70 (q, 2H, J=8.5 Hz), 4.04-4.18 (m, 2H), 4.48 (d, 2H, J=4.0 Hz), 4.97 (m, 1H), 7.70 (d, 1H, J=3.0 Hz), 8.28 (d, 1H, J=3.0 Hz), 9.00 (s, 2H), 9.22 (s, 1H); MS (CI/NH3) m/z 278 (M+H)+. Anal. Calcd for C13H13ClN4O.1.5 HCl.0.1 H2O: C, 46.86; H, 4.45; N, 16.81. Found: C, 47.11; H, 4.63; N, 16.42. [α]25D -9.20 (c 0.25, MeOH).

Quelle