Reaktion #453064

Reaktionsgleichung

HCl

5-ethenyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine

hydrogen chloride

MeOH

→

3-(2-(S)-Azetidinylmethoxy)-5-ethenylpyridine dihydrochloride

Lösungsmittel

Et2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigeto afford the tittle compound

Vorschrift

To a solution of 5-ethenyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine in Et2O was added hydrogen chloride (1.0 M in Et2O) carefully to afford the tittle compound: mp 88-90° C. 1H NMR (D2O) δ 2.64-2.78 (m, 2H), 4.04-4.22 (m, 2H), 4.50 (d, 1H, J=4.0 Hz), 4.80 (m, 1H), 4.96 (m, 1H), 5.58 (dd, 1H, J=11.0 Hz), 6.04 (d, 1H, J=18.0 Hz), 6.83 (dd, 1H, J=11.0, 18.0 Hz), 7.85 (t, 1H, J=2.0 Hz), 8.31 (br s, 1H), 8.36 (br s, 1H); MS (CI/NH3) m/z 191 (M+H)+. Anal. Calcd for C11H14N2O.1.8 HCl: C, 51.64; H, 6.22; N, 10.95. Found: C, 51.59; H, 5.92; N, 10.75. [α]25D +2.58 (c 0.62, MeOH).

Quelle