Reaktion #4529

Reaktionsgleichung

α-chloroethyl furfuryl carbonate

ethyl glycinate

water

NaCl

→

expected product

Ausbeute 66.0%

ethyl furfuryloxycarbonyl-glycinate

Ausbeute 66.0%

Lösungsmittel

THF

potassium carbonate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturmaintained at between 5° and 10° C
2. 2
   Sonstigeto come to room temperature
3. 3
   Extraktionthe mixture is extracted with 3×40 ml of ethyl ether
4. 4
   Trocknendried over magnesium sulphate

Vorschrift

2.05 g (10 mmol) of α-chloroethyl furfuryl carbonate are added to a solution of 1.03 g (10 mmol) of ethyl glycinate in 6 ml of THF and 4 ml of 0.5M potassium carbonate solution maintained at between 5° and 10° C. The mixture is allowed to come to room temperature and is stirred for 18 hours. 50 ml of water saturated with NaCl are added and the mixture is extracted with 3×40 ml of ethyl ether. The organic phases are combined and dried over magnesium sulphate. After removal of the solvent and distillation, 1.5 g (66% yield) of the expected product is collected.

Quelle