Reaktion #45286

Reaktionsgleichung

benzophenone imine

aminoacetonitrile hydrochloride

→

(benzhydrylideneamino)acetonitrile

Ausbeute 157.5%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered
2. 2
   Sonstigeto remove the precipitated ammonium chloride
3. 3
   Sonstigethe filtrate was evaporated to dryness in vacuo
4. 4
   workup.DISSOLUTIONThe resulting residue was dissolved in ether (400 mL)
5. 5
   Waschenwashed with water (200 mL) and brine
6. 6
   TrocknenAfter drying over magnesium sulfate the solution
7. 7
   Sonstigewas evaporated

Vorschrift

A mixture of benzophenone imine (25 g, 0.138 mol, Aldrich) and aminoacetonitrile hydrochloride (25 g, 0.270 mol, Lancaster) in dichloromethane (1000 mL) was stirred in a 2 L Erlenmeyer flask under nitrogen at room temperature for 5 days. The reaction mixture was filtered to remove the precipitated ammonium chloride and the filtrate was evaporated to dryness in vacuo. The resulting residue was dissolved in ether (400 mL) washed with water (200 mL) and brine. After drying over magnesium sulfate the solution was evaporated to give (benzhydrylideneamino)acetonitrile (47.89 g).

Quelle