Reaktion #452567

Reaktionsgleichung

6-amino-4-(4-benzyloxyanilino)quinazoline hydrochloride

→

6-amino-4-(4-benzyloxyanilino)quinazoline

Ausbeute 83.3%

Lösungsmittel

methanol THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe volatiles were removed under reduced pressure
2. 2
   workup.DISSOLUTIONThe crystalline brown residue was partially redissolved in MeOH (25 mL)
3. 3
   workup.ADDITIONdilute aqueous Na2CO3 solution (0.1 M, 50 mL) was added with vigourous stirring
4. 4
   Filtrationthe precipitate was collected by Buchner filtration
5. 5
   Waschenrinsed with water (50 mL)
6. 6
   Sonstigedried in a vacuum oven at 60° C.
7. 7
   Sonstigepurified by flash chromatography on silica gel
8. 8
   Wascheneluting with CHCl3

Vorschrift

A solution of 6-amino-4-(4-benzyloxyanilino)quinazoline hydrochloride (1.46 g, 3.57 mmol) in methanol/THF (1:1, 100 mL) was hydrogenated over Raney nickel (1 g) at 51.5 psi and 23° C. for 18 hours. The reaction mixture was celite filtered, and the volatiles were removed under reduced pressure. The crystalline brown residue was partially redissolved in MeOH (25 mL), and dilute aqueous Na2CO3 solution (0.1 M, 50 mL) was added with vigourous stirring. After 2 hours, the precipitate was collected by Buchner filtration, rinsed with water (50 mL), dried in a vacuum oven at 60° C., and then purified by flash chromatography on silica gel, eluting with CHCl3 then 4% MeOH in CHCl3 to give 6-amino-4-(4-benzyloxyanilino)quinazoline (1.018 g, 80%) as a cream powder; mp 173-175° C., remelt 240-245° C. Calculated for C20H16N4O.0.67 H2O: C, 71.16; H, 5.50; N, 15.81%. Found: C, 71.03; H, 5.38; N, 13.48%. 1H NMR (DMSO-d6); δ9.25 (1 H, brs), 8.25 (1 H,s), 7.70 (2 H, d, J=9.0 Hz), 7.52-7.47 (3 H, m), 7.41 (2 H, t, J=7.5 Hz), 7.38-7.35 (2 H, m), 7.02 (2 H, d, J=9.0 Hz), 5.54 (2 H, brs), 5.11 (2 H, s). Mass spectrum (APCI) 343 (100 MH+).

Quelle