Reaktion #452489

Reaktionsgleichung

sodium hydroxide

7-(3-chloropropoxy)-2,3,4,5-tetrahydro-1H-benzoazepin-2-one

1-(2-quinolylmethyl)piperazine

→

title compound

Ausbeute 50.6%

7-{3-[4-(2-quinolylmethyl)-1-piperazinyl]propoxy}-2,3,4,5-tetrahydro-1H-1-benzoazepin-2-one

Ausbeute 50.6%

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with water
2. 2
   Trocknendried over magnesium sulfate
3. 3
   SonstigeAfter the resulting solution was purified
4. 4
   Sonstigeon a silica gel column (developer: chloroform/methanol=40/1), recrystallization

Vorschrift

A mixture consisting of 7-(3-chloropropoxy)-2,3,4,5-tetrahydro-1H-benzoazepin-2-one (0.304 g, 1.2 mmol) and 1-(2-quinolylmethyl)piperazine (1.091 g, 4.8 mmol) was stirred for 4 hours at a bath temperature of 150° C. under an argon gas stream. The reaction mixture was dissolved in chloroform. The thus-obtained solution was rendered basic with a dilute aqueous solution of sodium hydroxide, washed with water, and then dried over magnesium sulfate. After the resulting solution was purified by subjecting it to chromatography on a silica gel column (developer: chloroform/methanol=40/1), recrystallization was conducted from acetone. The title compound (0.270 g) was obtained as yellow prisms (yield: 50.6%).

Quelle