Reaktion #452484

Reaktionsgleichung

1-bromo-3-chloropropane

1-(2-quinolylmethyl)piperazine

potassium carbonate

→

title compound

Ausbeute 65.7%

1-(3-chloropropyl)-4-(2-quinolylmethyl)piperazine

Ausbeute 65.7%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturunder reflux
3. 3
   Sonstigeinsoluble matter was removed
4. 4
   workup.DISTILLATIONthe solvent was distilled off
5. 5
   workup.DISSOLUTIONThe oil residue was dissolved in chloroform

Vorschrift

A mixture consisting of 1-(2-quinolylmethyl)piperazine (21.75 g, 95.7 mmol), potassium carbonate (19.90 g, 144 mmol), 1-bromo-3-chloropropane (16.57 g, 105 mmol) and acetone (250 ml) was heated under reflux and stirring for 20 hours, insoluble matter was removed and the solvent was distilled off. The oil residue was dissolved in chloroform and the resulting solution was then subjected to chromatography on a silica gel column (developer: chloroform/methanol=100/1), whereby 19.10 g of the title compound were obtained as a yellow oil (yield: 65.7%).

Quelle