Reaktion #452191

ord-b7f251e1487e4b86a37ec0a1cb18937c

Reaktionsgleichung

CN(C)Cc1ccnc(CSCCNC(=N)N)c1.CN(C)Cc1ccnc(CSCCNC(=N)N)c1.O=S(=O)(O)O
N-[2-(4-dimethylaminomethyl-2-pyridylmethylthio)ethyl]guanidine hemisulphate
CCOC(=O)C(C=O)CCc1ccc(C)nc1
ethyl 2-formyl-3-(6-methyl-3-pyridylmethyl)propionate
CC[O-].[Na+]
sodium ethoxide
→
Cc1ccc(Cc2cnc(NCCSCc3cc(CN(C)C)ccn3)[nH]c2=O)cn1
2-[2-(4-dimethylaminomethyl-2-pyridyl-methylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone

Edukte

CN(C)Cc1ccnc(CSCCNC(=N)N)c1.CN(C)Cc1ccnc(CSCCNC(=N)N)c1.O=S(=O)(O)O
N-[2-(4-dimethylaminomethyl-2-pyridylmethylthio)ethyl]guanidine hemisulphate
CCOC(=O)C(C=O)CCc1ccc(C)nc1
ethyl 2-formyl-3-(6-methyl-3-pyridylmethyl)propionate
CC[O-].[Na+]
sodium ethoxide

Reagenzien

Keine

Lösungsmittel

CCO
ethanol

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

Reaction of N-[2-(4-dimethylaminomethyl-2-pyridylmethylthio)ethyl]guanidine hemisulphate with ethyl 2-formyl-3-(6-methyl-3-pyridylmethyl)propionate and sodium ethoxide in ethanol gives 2-[2-(4-dimethylaminomethyl-2-pyridyl-methylthio)ethylamino]-5-(6-methyl-3-pyridylmethyl)-4-pyrimidone.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04607107uspto-grants-1986_08