Reaktion #452142

Reaktionsgleichung

diethyl 4-(4-benzofurazanyl)-2-diethoxymethyl-1,4,5,6-tetrahydro-6-hydroxy-6-(trifluoromethyl)-3,5-pyridinedicarboxylate

trifluoroacetic anhydride

pyridine

→

Diethyl 4-(4-benzofurazanyl)-2-diethoxymethyl-1,4-dihydro-6-trifluoromethyl-3,5-pyridinedicarboxylate

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenAfter 3 hours the solution was washed with water, 10% aqueous hydrochloric acid solution, brine
2. 2
   Trocknendried (MgSO4)
3. 3
   SonstigeEvaporation of the solvent
4. 4
   workup.WAITleft crude sub-title compound as an oil (8.8 g)

Vorschrift

A solution of diethyl 4-(4-benzofurazanyl)-2-diethoxymethyl-1,4,5,6-tetrahydro-6-hydroxy-6-(trifluoromethyl)-3,5-pyridinedicarboxylate (9.0 g, 17 mmoles), trifluoroacetic anhydride (4.77 ml, 34 mmoles) and pyridine (4.05 ml, 51 mmoles) in dry dichloromethane (100 ml) was stirred at room temperature. After 3 hours the solution was washed with water, 10% aqueous hydrochloric acid solution, brine and dried (MgSO4). Evaporation of the solvent left crude sub-title compound as an oil (8.8 g). Nmr (CDCl3) δ 6.1 (s,H), 5.6(s,H).

Quelle