Reaktion #452076

ord-099715e9b0204e519f67ab46d01adaef

Reaktionsgleichung

CN(C)C=NS(=O)(=O)c1cc(C(C)(C)C)cc(CNC(=O)CCl)c1O
2-chloro-N-[5-(1,1-dimethylethyl)-3 -dimethylaminomethyleneaminosulfonyl-2-hydroxybenzyl]-acetamide
→
CC(C)(C)c1cc(CN)c(O)c(S(N)(=O)=O)c1.Cl
2-Aminomethyl-4-(1,1-dimethylethyl)-6-sulfamoylphenol hydrochloride

Edukte

CN(C)C=NS(=O)(=O)c1cc(C(C)(C)C)cc(CNC(=O)CCl)c1O
2-chloro-N-[5-(1,1-dimethylethyl)-3 -dimethylaminomethyleneaminosulfonyl-2-hydroxybenzyl]-acetamide

Reagenzien

Keine

Lösungsmittel

CCO
ethanol
Cl
hydrochloric acid

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Temperaturare heated
  2. 2
    Temperaturunder reflux for 2 hours
  3. 3
    SonstigeThe solvent is removed in vacuo
  4. 4
    Sonstigethe residue is crystallized from methanol/ether

Vorschrift

3 g (0.008 mole) of 2-chloro-N-[5-(1,1-dimethylethyl)-3 -dimethylaminomethyleneaminosulfonyl-2-hydroxybenzyl]-acetamide in a mixture of 30 ml of ethanol and 3 ml of concentrated hydrochloric acid are heated under reflux for 2 hours. The solvent is removed in vacuo and the residue is crystallized from methanol/ether.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04607030uspto-grants-1986_08