Reaktion #45196

ord-f4e92310340d471eb12c529b5ed748ee

Reaktionsgleichung

OC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O[C@H]5[C@H](O)[C@@H](O)[C@@H](O[C@H]6[C@H](O)[C@@H](O)[C@@H](O[C@H]7[C@H](O)[C@@H](O)[C@@H](O[C@H]1[C@H](O)[C@H]2O)O[C@@H]7CO)O[C@@H]6CO)O[C@@H]5CO)O[C@@H]4CO)O[C@@H]3CO

→

Alpha-Lipoic Acid Alpha Cyclodextrin

Edukte

Reagenzien

Keine

Lösungsmittel

water

Reaktionsbedingungen

Detaillierte Bedingungen

See reaction.notes.procedure_details.

Aufarbeitung

1
workup.ADDITIONmixed at room temperature until clear
2
workup.ADDITIONmixed until clear (in case of the presence of amorphous silica
3
Sonstigeprecipitating the complex
4
workup.STIRRINGThis mixture was stirred 55 minutes at room temperature
5
Sonstigedried immediately at about 180° C. inlet
6
Sonstigeabout 80° C. outlet temperature

Vorschrift

29.95 kg of potassium hydroxide pellets (87.9%, 469.3 moles) were added to 1920.0 kg of water and mixed at room temperature until clear. The pH of this solution was at pH 14. 97.8 kg alpha-lipoic acid (98%, 464.5 moles) was added to the potassium hydroxide solution and mixed until clear (in case of the presence of amorphous silica as flowing agent the solution will be slightly cloudy). 555.1 kg alpha cyclodextrin (8.9% water content, 520.3 moles) was added and stirred 60 minutes at room temperature. 469.3 moles of 37.7% hydrochloric acid was added precipitating the complex. This mixture was stirred 55 minutes at room temperature. The final pH was at about pH 3. The final aqueous mixture was spray dried immediately at about 180° C. inlet and about 80° C. outlet temperature.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07737269B2uspto-grants-2010_06