Reaktion #45146

Reaktionsgleichung

N,N-dimethylpyrrolidin-3-amine

5-chloro-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]pyrazine-2-carboxamide

→

title compound

Ausbeute 80.0%

N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-5-(3-dimethylaminopyrrolidin-1-yl)pyrazine-2-carboxamide

Ausbeute 80.0%

Lösungsmittel

methanol

dimethylsulfoxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe crude product was purified by ion exchange chromatography
2. 2
   WaschenThe desired product was eluted from the column
3. 3
   Sonstigewere evaporated to dryness
4. 4
   Sonstigeto afford impure product as a brown oil
5. 5
   SonstigeThe crude product was purified by preparative HPLC
6. 6
   workup.ADDITIONFractions containing the desired compound
7. 7
   Sonstigewere evaporated to dryness

Vorschrift

N,N-dimethylpyrrolidin-3-amine (114 mg, 1.00 mmol) was added to 5-chloro-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]pyrazine-2-carboxamide (136 mg, 0.35 mmol) in anhydrous dimethylsulfoxide (1.75 ml) at 25° C. The resulting solution was stirred at room temperature for 20 mins. The reaction mixture was diluted with methanol (5.00 ml) and the crude product was purified by ion exchange chromatography, using a SCX column. The desired product was eluted from the column using 7M NH3/MeOH and fractions were evaporated to dryness to afford impure product as a brown oil. The crude product was purified by preparative HPLC, using decreasingly polar mixtures of water (containing 1% NH3) and MeCN as eluents. Fractions containing the desired compound were evaporated to dryness to afford the title compound (130 mg, 80%) as a white solid.

Quelle