Reaktion #451218

Reaktionsgleichung

1-(phenylmethyl)-N-(2,2,2-trifluoroethyl)-3-pyrrolidinemethanamine

hydrogen

→

N-(2,2,2-trifluoroethyl)-3-pyrrolidinemethanamine

Ausbeute 53.2%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe catalyst was filtered
2. 2
   Sonstigethe filtrate evaporated under reduced pressure
3. 3
   workup.DISTILLATIONThe residue was distilled under vacuum (63°-65° C., 2.8 mm Hg)

Vorschrift

A mixture of 7.15 g (26.3 mmole) 1-(phenylmethyl)-N-(2,2,2-trifluoroethyl)-3-pyrrolidinemethanamine 100 ml of methanol and 0.7 g of 20% palladium on carbon was shaken in an atmosphere of hydrogen at about 50 psi and at room temperature for 24 hours. The catalyst was filtered and the filtrate evaporated under reduced pressure. The residue was distilled under vacuum (63°-65° C., 2.8 mm Hg) to give 2.55 g of N-(2,2,2-trifluoroethyl)-3-pyrrolidinemethanamine.

Quelle