Reaktion #45098

Reaktionsgleichung

HCl

dioxane

tert-butyl 4-cyclopropylpiperazine-1-carboxylate

→

1-cyclopropylpiperazine dihydrochloride

Ausbeute 93.0%

Lösungsmittel

methanol

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe white solid filtered off

Vorschrift

4.0M HCl in dioxane (42.7 mL, 170.78 mmol) was added to a stirred solution of tert-butyl 4-cyclopropylpiperazine-1-carboxylate (7.73 g, 34.16 mmol) in a mixture of methanol (50.0 mL) and ethyl acetate (200 mL). The resulting suspension was stirred at room temperature for 24 h under nitrogen. The white solid filtered off to give 1-cyclopropylpiperazine dihydrochloride (6.30 g, 93%).

Quelle