Reaktion #45078

Reaktionsgleichung

carbonate

5-[(3,5-dimethoxyphenyl)methoxy]-2H-pyrazol-3-amine hydrochloride

→

5-[(3,5-dimethoxyphenyl)methoxy]-2H-pyrazol-3-amine

Ausbeute 67.5%

Lösungsmittel

methanol

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered
2. 2
   WaschenMP carbonate was washed with 10% MeOH in DCM
3. 3
   SonstigeThis was evaporated to dryness

Vorschrift

MP carbonate (2.74 mmol/g) (12.00 g, 32.88 mmol) was added to 5-[(3,5-dimethoxyphenyl)methoxy]-2H-pyrazol-3-amine hydrochloride (5 g, 17.50 mmol) in methanol (200 mL) and water (20 mL). The resulting suspension was stirred at room temperature for 18 h. The reaction mixture was filtered and MP carbonate was washed with 10% MeOH in DCM. This was evaporated to dryness to afford 5-[(3,5-dimethoxyphenyl)methoxy]-2H-pyrazol-3-amine (2.94 g, 67.5%) as an orange waxy solid.

Quelle