Reaktion #4507

Reaktionsgleichung

4-bromoacetyl-5-methyl-2-phenyloxazole

p-cyanophenol

potassium carbonate

→

4-[2-(5-methyl-2-phenyl-4-oxazolyl)-2-oxoethoxy]benzonitrile

Ausbeute 79.2%

Lösungsmittel

methyl ethyl ketone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturunder reflux for 2 hours
3. 3
   EinengenThe reaction mixture was concentrated under reduced pressure, and water (100 ml)-ether (100 ml)
4. 4
   workup.ADDITIONwas added to the residue
5. 5
   Filtrationthe crystals were collected by filtration
6. 6
   SonstigeRecrystallization from chloroform-ethanol

Vorschrift

A mixture of 4-bromoacetyl-5-methyl-2-phenyloxazole (7.0 g), p-cyanophenol (3.0 g), potassium carbonate (6.9 g) and methyl ethyl ketone (100 ml) was heated under reflux for 2 hours. The reaction mixture was concentrated under reduced pressure, and water (100 ml)-ether (100 ml) was added to the residue. The mixture was stirred, and the crystals were collected by filtration. Recrystallization from chloroform-ethanol afforded 4-[2-(5-methyl-2-phenyl-4-oxazolyl)-2-oxoethoxy]benzonitrile (6.3 g, 78.8%), as brownish prisms, m.p. 202°-203° C.

Quelle