Reaktion #45057

Reaktionsgleichung

tert-butyl 4-cyclopropylpiperazine-1-carboxylate

1,4-dioxane

→

1-cyclopropylpiperazine

Ausbeute 59.8%

Lösungsmittel

HCl

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction mixture was filtered
2. 2
   Waschenwashed with ether
3. 3
   Sonstigeto afford crude 1-cyclopropylpiperazine (0.659 g) as a white solid
4. 4
   SonstigeThe crude product was purified by ion exchange chromatography
5. 5
   WaschenThe desired product was eluted from the column
6. 6
   Sonstigewere evaporated to dryness

Vorschrift

A solution of tert-butyl 4-cyclopropylpiperazine-1-carboxylate (0.792 g, 3.50 mmol) in 4M HCl in 1,4-dioxane (4.37 mL, 17.50 mmol) was stirred at room temperature for 3 h under nitrogen. The reaction mixture was filtered and washed with ether to afford crude 1-cyclopropylpiperazine (0.659 g) as a white solid. The crude product was purified by ion exchange chromatography, using a SCX column. The desired product was eluted from the column using 3.5M NH3/MeOH and pure fractions were evaporated to dryness to afford 1-cyclopropylpiperazine (0.264 g, 59.7%) as a yellow oil.

Quelle