Reaktion #45035

Reaktionsgleichung

NaHMDS

NH4Cl

NH4Cl

tert-Butyl 5-amino-3-[(3,5-dimethoxyphenyl)methoxy]pyrazole-1-carboxylate

NaHMDS

tert-butyl 5-amino-3-[(3,5-dimethoxyphenyl)methoxy]pyrazole-1-carboxylate

methyl 2-(4-methylpiperazin-1-yl)pyrimidine-5-carboxylate

→

title compound

Ausbeute 14.0%

N-[5-[(3,5-Dimethoxyphenyl)methoxy]-1H-pyrazol-3-yl]-2-(4-methylpiperazin-1-yl)pyrimidine-5-carboxamide

Ausbeute 14.0%

Lösungsmittel

water

water

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with ethyl acetate (3×15 ml)
2. 2
   TrocknenThe combined organic extracts were dried over MgSO4
3. 3
   Filtrationfiltered
4. 4
   Sonstigeevaporated
5. 5
   Sonstigeto give an orange gum
6. 6
   SonstigeThe gum was purified by silica column chromatography
7. 7
   Wascheneluting with a gradient of 0-2.5% MeOH in DCM
8. 8
   workup.ADDITIONThe crude material, containing
9. 9
   workup.DISSOLUTIONwas re-dissolved in THF (5 ml) under nitrogen
10. 10
    workup.STIRRINGThe solution was stirred at room temperature for 45 mins
11. 11
    Extraktionextracted with ethyl acetate (3×10 ml)
12. 12
    TrocknenThe combined organic extracts were dried over MgSO4
13. 13
    Filtrationfiltered
14. 14
    Sonstigeevaporated
15. 15
    SonstigeThe gummy residue was purified by silica column chromatography
16. 16
    Wascheneluting with a gradient of 0-8% MeOH in DCM

Vorschrift

NaHMDS (1M solution in THF, 0.39 ml, 0.386 mmol, 1.5 eq) was added dropwise to a stirred solution of tert-butyl 5-amino-3-[(3,5-dimethoxyphenyl)methoxy]pyrazole-1-carboxylate (90 mg, 0.258 mmol, 1 eq) and methyl 2-(4-methylpiperazin-1-yl)pyrimidine-5-carboxylate (74 mg, 0.309 mmol, 1.2 eq) in dry THF (5 ml) under nitrogen. The solution was stirred at room temperature for 1 h, then neutralised with satd. aq. NH4Cl, diluted with water (15 ml) and extracted with ethyl acetate (3×15 ml). The combined organic extracts were dried over MgSO4, filtered and evaporated to give an orange gum. The gum was purified by silica column chromatography, eluting with a gradient of 0-2.5% MeOH in DCM. The crude material, containing starting methyl 2-(4-methylpiperazin-1-yl)pyrimidine-5-carboxylate, was re-dissolved in THF (5 ml) under nitrogen. tert-Butyl 5-amino-3-[(3,5-dimethoxyphenyl)methoxy]pyrazole-1-carboxylate (50 mg, 0.143 mmol) was added followed by dropwise addition of NaHMDS (1M solution in THF, 0.32 ml, 0.32 mmol). The solution was stirred at room temperature for 45 mins, neutralised with satd. aq. NH4Cl, diluted with water (10 ml) and extracted with ethyl acetate (3×10 ml). The combined organic extracts were dried over MgSO4, filtered and evaporated. The gummy residue was purified by silica column chromatography, eluting with a gradient of 0-8% MeOH in DCM, to afford the title compound as a pale brown solid (16 mg, 14% yield); 1H NMR (399.9 MHz, DMSO-d6+d4-AcOD) δ 2.42 (3H, s), 2.67-2.70 (4H, m), 3.75 (6H, s), 3.91-3.94 (4H, m), 5.08 (2H, s), 5.75 (1H, s), 6.45 (1H, t), 6.59 (2H, d), 8.90 (2H, s). MS: m/z 454 (MH+)

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