Reaktion #4502

Reaktionsgleichung

4-{2-[2-(4-benzyloxyphenyl)-5-methyl-4-oxazolyl]ethoxy}nitrobenzene

→

4-{2-[2-(4-hydroxyphenyl)-5-methyl-4-oxazolyl]ethoxy}aniline

Ausbeute 80.9%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationAfter the catalyst was filtered off
2. 2
   Einengenthe filtrate was concentrated

Vorschrift

A solution of 4-{2-[2-(4-benzyloxyphenyl)-5-methyl-4-oxazolyl]ethoxy}nitrobenzene (10.65 g) in methanol (200 ml) was subjected to a catalytic hydrogenation over 10% Pd-C (50% wet, 4.0 g). After the catalyst was filtered off, the filtrate was concentrated to give 4-{2-[2-(4-hydroxyphenyl)-5-methyl-4-oxazolyl]ethoxy}aniline (6.21 g, 78.2%). Recrystallization from methanol afforded brownish prisms, m.p. 184°-185° C. Elemental analysis for C18H18N2O3 ; Calcd.: C, 69.66; H, 5.85; N, 9.03. Found: C, 69.69; H, 5.87; N, 9.01.

Quelle