Reaktion #449875

Reaktionsgleichung

2,4-di-tert-butylphenol

NaOEt

ethyl 2-bromocaproate

→

ethyl 2-(2,4-di-tert-butylphenoxy)caproate

Ausbeute 98.0%

Lösungsmittel

EtOH

EtOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigesimultaneously in the course of 1 hour
2. 2
   workup.DISTILLATIONwas distilled off
3. 3
   workup.ADDITIONAfter the addition
4. 4
   TemperaturThe mixture was cooled to 90° C.
5. 5
   workup.ADDITION250 ml of water were added
6. 6
   SonstigeAfter separation of the phases
7. 7
   Waschenwashing with 200 ml of water, 347 g of a viscous yellow oil of the following composition (0.3% of ethyl bromocaproate, 0.5% of residual phenol and 98% of ethyl 2-(2,4-di-tert-butylphenoxy)caproate

Vorschrift

206 g (1 mol) of 2,4-di-tert-butylphenol were melted and heated to 140° C. under nitrogen. 234 g (1.03 mol) of a 30% strength NaOEt solution in EtOH and 245 g (1.1 mol) of ethyl 2-bromocaproate were metered in simultaneously in the course of 1 hour. During the addition, EtOH was distilled off. After the addition, the reaction was ended. The mixture was cooled to 90° C. and 250 ml of water were added. After separation of the phases and washing with 200 ml of water, 347 g of a viscous yellow oil of the following composition (0.3% of ethyl bromocaproate, 0.5% of residual phenol and 98% of ethyl 2-(2,4-di-tert-butylphenoxy)caproate, remained. This corresponds to a yield of 98% of theory, based on the phenol employed.

Quelle