Reaktion #44977

Reaktionsgleichung

ethyl isonicotinate

4-Chloropyridine hydrochloride

triethylamine

→

title compound

Ausbeute 78.7%

1-Pyridin-4-ylpiperidin-4-carboxylic Acid

Ausbeute 78.7%

Lösungsmittel

water

ethanol

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto cool
2. 2
   Sonstigethe insoluble materials are removed by filtration
3. 3
   EinengenThe filtrate is concentrated under reduced pressure
4. 4
   FiltrationThe precipitates are collected by filtration
5. 5
   Sonstigerecrystallized from water/N,N-dimethylformamide

Vorschrift

4-Chloropyridine hydrochloride (9.55 g) and triethylamine (26.0 ml) are dissolved in ethanol (10 ml) and water (30 ml), and thereto is added ethyl isonicotinate (10.00 g). The reaction solution is then heated at 150° C. for 96 hours in a sealed tube. After allowing to cool, ethanol is added to the reaction solution and the insoluble materials are removed by filtration. The filtrate is concentrated under reduced pressure, and the resulting residue is suspended in chloroform. The precipitates are collected by filtration and recrystallized from water/N,N-dimethylformamide to give the title compound (10.34 g).

Quelle