Reaktion #44969

ord-cb291f84b81746028f3034c14590734a

Reaktionsgleichung

O=C(CCCCN1CCOCC1=O)Nc1c(C(=O)Nc2ccc(Cl)cn2)oc2ccc(C(=O)O)nc12
2-{[(5-Chloropyridin-2-yl)amino]carbonyl}-3-{[5-(3-oxomorpholin-4-yl)pentanoyl]amino}furo[3,2-b]pyridine-5-carboxylic acid
CNCCOC
N-(2-methoxyethyl)methylamine
→
COCCN(C)C(=O)c1ccc2oc(C(=O)Nc3ccc(Cl)cn3)c(NC(=O)CCCCN3CCOCC3=O)c2n1
title compound
Ausbeute 75.0%
COCCN(C)C(=O)c1ccc2oc(C(=O)Nc3ccc(Cl)cn3)c(NC(=O)CCCCN3CCOCC3=O)c2n1
N2-(5-Chloropyridin-2-yl)-N5-(methoxyethyl)-N5-methyl-3-{[5-(3-oxomorpholin-4-yl)pentanoyl]amino}furo[3,2-b]pyridine-2,5-dicarboxamide
Ausbeute 75.0%

Edukte

O=C(CCCCN1CCOCC1=O)Nc1c(C(=O)Nc2ccc(Cl)cn2)oc2ccc(C(=O)O)nc12
2-{[(5-Chloropyridin-2-yl)amino]carbonyl}-3-{[5-(3-oxomorpholin-4-yl)pentanoyl]amino}furo[3,2-b]pyridine-5-carboxylic acid
CNCCOC
N-(2-methoxyethyl)methylamine

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

2-{[(5-Chloropyridin-2-yl)amino]carbonyl}-3-{[5-(3-oxomorpholin-4-yl)pentanoyl]amino}furo[3,2-b]pyridine-5-carboxylic acid (82 mg) obtained in Example 139 and N-(2-methoxyethyl)methylamine (28 mg) are treated in a similar manner to Example 85 to give the title compound (70 mg).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07737161B2uspto-grants-2010_06