Reaktion #44965

Reaktionsgleichung

t-Butyl {3-[(trans-4-{[(2-{[(5-chloropyridin-2-yl)amino]carbonyl}-furo[3,2-b]pyridin-3-yl)amino]carbonyl}cyclohexyl)(methyl)amino]-propyl}carbamate

t-Butyl {3-[(trans-4-{[(2-{[(5-chloropyridin-2-yl)amino]-carbonyl}furo[3,2-b]pyridin-3-yl)amino]carbonyl}cyclohexyl)(methyl)-amino]propyl}carbamate

hydrogen chloride dioxane

→

title compound

Ausbeute 93.8%

3-[({Trans-4-[(3-aminopropyl)(methyl)amino]cyclohexyl}-carbonyl)amino]-N-(5-chloropyridin-2-yl)furo[3,2-b]pyridine-2-carboxamide

Ausbeute 93.8%

Lösungsmittel

dioxane

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction solution is concentrated under reduced pressure
2. 2
   FiltrationThe precipitates are collected by filtration
3. 3
   workup.ADDITIONis added saturated aqueous sodium hydrogen carbonate solution
4. 4
   Sonstigethe organic layer is separated
5. 5
   WaschenThe organic layer is washed with saturated brine
6. 6
   Trocknendried over sodium sulfate
7. 7
   Sonstigethe solvent is evaporated under reduced pressure

Vorschrift

t-Butyl {3-[(trans-4-{[(2-{[(5-chloropyridin-2-yl)amino]carbonyl}-furo[3,2-b]pyridin-3-yl)amino]carbonyl}cyclohexyl)(methyl)amino]-propyl}carbamate (265 mg) obtained in Example 120 is dissolved in dioxane (3 ml), and thereto is added 4N hydrogen chloride-dioxane solution (6 ml), and the mixture is stirred at room temperature for 20 hours. The reaction solution is concentrated under reduced pressure, and the residue is suspended in diethyl ether. The precipitates are collected by filtration. The resulting solid is suspended in chloroform, and thereto is added saturated aqueous sodium hydrogen carbonate solution, and the organic layer is separated. The organic layer is washed with saturated brine, dried over sodium sulfate, and the solvent is evaporated under reduced pressure to give the title compound (206 mg).

Quelle