Reaktion #449580

Reaktionsgleichung

2-methylaniline

4-[(6,11-dihydro-5H-dibenz[b,e]azepin-5-yl)carbonyl]benzoyl chloride

triethylamine

→

crystals

Ausbeute 5.8%

4-[(6,11-Dihydro-5H-dibenz[b,e]azepin-5-yl)carbonyl]-N-(2-methylphenyl)benzamide

Ausbeute 5.8%

Lösungsmittel

dichloromethane

dichloromethane

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Waschenwashed with H2O 1N HCl, 1M NaHCO3, brine
2. 2
   Trocknendried (Na2SO4)
3. 3
   SonstigeThe solvent is removed
4. 4
   Sonstigeto give a solid
5. 5
   Filtrationfiltered through a thin pad of hydrous magnesium silicate with dichloromethane as eluent

Vorschrift

To a mixture of 0.362 g of 4-[(6,11-dihydro-5H-dibenz[b,e]azepin-5-yl)carbonyl]benzoyl chloride and 0.101 g of triethylamine in 5 ml of dichloromethane is added a solution of 0.129 g of 2-methylaniline in 3 ml of dichloromethane. The mixture is stirred 1.5 hr at room temperature and then washed with H2O 1N HCl, 1M NaHCO3, brine and dried (Na2SO4). The solvent is removed to give a solid. The solid is dissolved in dichloromethane and filtered through a thin pad of hydrous magnesium silicate with dichloromethane as eluent to give 0.025 g of crystals, m.p. 214°-216° C.

Quelle