Reaktion #44953

Reaktionsgleichung

Pseudomonic acid

potassium hydroxide

calcium chloride

→

final product

Ausbeute 93.3%

Mupirocin Calcium

Ausbeute 93.3%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe solution was then filtered
2. 2
   Sonstigeto remove potassium chloride (0.60 g)
3. 3
   SonstigeThe methanol was then evaporated at reduced pressure
4. 4
   Sonstigeto give a solid, white foam
5. 5
   SonstigeThe product was dried for 12 hours at 45° C. under vacuum

Vorschrift

Pseudomonic acid (5.00 g, 10 mmole) was dissolved in methanol (5.5 ml), methanolic solution of potassium hydroxide (0.56 g, 10 mmole potassium hydroxide and 4 ml methanol) and methanolic solution of calcium chloride (0.56 g, 5.0 mmole calcium chloride and 5 ml methanol) were added to the mixture. The mixture was stirred for 1 hour. The solution was then filtered to remove potassium chloride (0.60 g). The methanol was then evaporated at reduced pressure to give a solid, white foam. The product was dried for 12 hours at 45° C. under vacuum to obtain 4.85 grams of final product. Assay: 95.9%, Water: 2.23% [total impurity: 3.19%, highest impurity: 1.23%-different method than assay], melting point: 85 to 89° C.

Quelle