Reaktion #449485

Reaktionsgleichung

phenacyl bromide

3-benzyloxyaniline

Na2CO3

→

2'-(3-benzyloxyphenylamino)acetophenone

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe mixture is then cooled
2. 2
   Einengenconcentrated in an RE
3. 3
   SonstigeThe residue is partitioned between water and methylene chloride
4. 4
   Extraktionthe aqueous phase is extracted twice with methylene chloride
5. 5
   TrocknenThe combined organic phases are dried over Na2SO4
6. 6
   Einengenconcentrated
7. 7
   Filtrationthe crystals are filtered off

Vorschrift

10 g of phenacyl bromide and 11 g of 3-benzyloxyaniline are stirred at 60° C. for 2 h in 100 ml of ethanol in the presence of 11.7 g of powdered Na2CO3. The mixture is then cooled and concentrated in an RE. The residue is partitioned between water and methylene chloride and the aqueous phase is extracted twice with methylene chloride. The combined organic phases are dried over Na2SO4 and concentrated. The residue is slurried with ether and the crystals are filtered off, 2'-(3-benzyloxyphenylamino)acetophenone being obtained.

Quelle