Reaktion #44945

ord-8008fe19544b41a79c4b95d0460d93c7

Reaktionsgleichung

C/C(=C\C(=O)OCCCCCCCCC(=O)[O-])C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O.C/C(=C\C(=O)OCCCCCCCCC(=O)[O-])C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O.[Ca+2]
mupirocin calcium
→
C/C(=C\C(=O)OCCCCCCCCC(=O)[O-])C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O.C/C(=C\C(=O)OCCCCCCCCC(=O)[O-])C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O.O.O.[Ca+2]
Mupirocin calcium dihydrate

Edukte

C/C(=C\C(=O)OCCCCCCCCC(=O)[O-])C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O.C/C(=C\C(=O)OCCCCCCCCC(=O)[O-])C[C@@H]1OC[C@H](C[C@@H]2O[C@H]2[C@@H](C)[C@H](C)O)[C@@H](O)[C@H]1O.[Ca+2]
mupirocin calcium

Reagenzien

Keine

Lösungsmittel

O
water

Reaktionsbedingungen

Temperatur
5°CELSIUS
Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    workup.WAITkept at this temperature for 15 hours
  2. 2
    workup.STIRRINGThen mixture was then stirred at 5° C. for 3 hours
  3. 3
    FiltrationThe crystalline product was filtered
  4. 4
    Sonstigedried in an air
  5. 5
    Sonstigeat room temperature

Vorschrift

Amorphous mupirocin calcium (14 g) was dissolved in water (35 ml) and stirred for one hour. The mixture was cooled to 5° C. and kept at this temperature for 15 hours. Then mixture was then stirred at 5° C. for 3 hours. The crystalline product was filtered and dried in an air circulated oven at room temperature. Mupirocin calcium dihydrate (12.5 g, 83%) was obtained.

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07737177B2uspto-grants-2010_06