Reaktion #4494

Reaktionsgleichung

butyramide

1.3-dichloroacetone

sodium bicarbonate

→

4-chloromethyl-2-propyloxazole

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturAfter cooling
2. 2
   Extraktionextracted with ethyl ether
3. 3
   WaschenThe extract was washed with water
4. 4
   Trocknendried (MgSO4)
5. 5
   Einengenconcentrated
6. 6
   SonstigeThe residue was purified by chromatography on silica gel with acetone-hexane (1:9)

Vorschrift

A mixture of butyramide (19.88 g) and 1.3-dichloroacetone (24.14 g) was heated at 130° C. for 1.5 hours. After cooling, the mixture was diluted with water, neutralized with aqueous sodium bicarbonate solution and extracted with ethyl ether. The extract was washed with water, dried (MgSO4) and concentrated. The residue was purified by chromatography on silica gel with acetone-hexane (1:9) to yield 4-chloromethyl-2-propyloxazole as an oil (10.70 g 35.3%). NMR (CDCl3)δ: 0.97 (3H, t, J=7.5 Hz), 1.79 (2H, sext, J=7.5 Hz), 2.72 (2H, t, J=7.5 Hz), 4.47 (2H, s), 7.53 (1H, s).

Quelle