Reaktion #449376

Reaktionsgleichung

4-Amino-3-pyridinol

1-piperidinylformamide dimethyl acetal

→

product

4-[[(1-Piperidinyl)methylene]amino]-3-pyridinol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstige(approximately one minute)
2. 2
   TemperaturThe reaction mixture was cooled
3. 3
   workup.WAITplaced in an ice bath for a half hour
4. 4
   FiltrationThe crystallized product was filtered
5. 5
   Waschenwashed well with diethyl ether, and air
6. 6
   Sonstigedried

Vorschrift

4-Amino-3-pyridinol (3.3 g) was added to 1-piperidinylformamide dimethyl acetal (50 ml) and the mixture was stirred at 100° C. until it became homogeneous (approximately one minute). The reaction mixture was cooled, and placed in an ice bath for a half hour. The crystallized product was filtered, washed well with diethyl ether, and air dried to yield 4.64 g of product. This was recrystallized from ethyl acetate and dried under high vacuum and refluxing ethanol overnight to yield 3.39 g of fluffy needles, m.p. 171°-172.5° C.

Quelle