Reaktion #44872

Reaktionsgleichung

tert-butyl 4-(aminomethyl)piperidine-1-carboxylate

1-isopropyl-1,3-dihydro-2H-benzimidazol-2one

triethylamine

triphosgene

NaHCO3

→

oil

Ausbeute 62.0%

tert-Butyl 4-({[(3-isopropyl-2-oxo-2,3-dihydro-1H -benzimidazol-1-yl)carbonyl]amino}methyl)piperidine-1-carboxylate

Ausbeute 62.0%

Lösungsmittel

tetrahydrofuran

tetrahydrofuran

tetrahydrofuran

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was refluxed for 19 hours
2. 2
   TemperaturThe reaction mixture was refluxed for another 24 hours
3. 3
   TemperaturThen cooled
4. 4
   Extraktionextracted with ethyl acetate 100 ml for three times
5. 5
   ExtraktionThe combined extract
6. 6
   Waschenwas washed with brine
7. 7
   Trocknendried over MgSO4
8. 8
   Einengenconcentrated

Vorschrift

To a stirred solution of 1-isopropyl-1,3-dihydro-2H-benzimidazol-2one (J. Med. Chem. 1999, 42, 2870-2880) (3.00 g, 17.02 mmol) and triethylamine (7.12 ml, 51.06 mmol) in 70 ml tetrahydrofuran was added triphosgene (5.15 g, 17.02 mmol) in 14 ml tetrahydrofuran at room temperature. The reaction mixture was refluxed for 19 hours. The mixture was then cooled to room temperature, tert-butyl 4-(aminomethyl)piperidine-1-carboxylate (J. Prugh, L. A. Birchenough and M. S. Egbertson, Synth. Commun., 1992, 22, 2357-60) (3.28 g, 15.32 mmol) in 10 ml tetrahydrofuran was added. The reaction mixture was refluxed for another 24 hours. Then cooled and basified with aqueous saturated NaHCO3 50 ml, and extracted with ethyl acetate 100 ml for three times. The combined extract was washed with brine, dried over MgSO4 and concentrated. Flash chromatography of the residue (elutent: hexane/ethyl acetate=5/1 to 1/2) afforded a colorless oil 3.99 g (62%) as the titled compound.

Quelle