Reaktion #44860

Reaktionsgleichung

tert-butyl (piperidin-4-ylmethyl)carbamate

paraformaldehyde

potassium carbonate

ethanol

→

title compound

tert-Butyl {[1-(ethoxymethyl)piperidin-4-yl]methyl}carbamate

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture was filtered
2. 2
   Waschenthe filter cake was washed with ethanol (50 mL)
3. 3
   SonstigeThe volatile components were removed by evaporation

Vorschrift

To a stirred solution of tert-butyl (piperidin-4-ylmethyl)carbamate (7.0 g, 33 mmol) in ethanol (19 mL), paraformaldehyde (1.2 g, 39 mmol) and potassium carbonate (5.4 g, 39 mmol) were added at ambient temperature. The mixture was stirred at ambient temperature for 4 h. The mixture was filtered and the filter cake was washed with ethanol (50 mL). The volatile components were removed by evaporation to give the title compound 8.9 g (quant.) as a white powder.

Quelle