Reaktion #44835

Reaktionsgleichung

2-chlorobenzimidazole

(S)-1,2,3,4-tetrahydro-1-naphthylamine

→

title compound

(S)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine

HCl

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe product was purified by preparative LCMS
2. 2
   workup.ADDITIONadded HCl

Vorschrift

The title compound was prepared from 2-chlorobenzimidazole and (S)-1,2,3,4-tetrahydro-1-naphthylamine by Procedure A (reflux in toluene for 2 days). The product was purified by preparative LCMS, added HCl and isolated as a HCl salt (white solid, mp 257-258° C.). MS(ES+) m/z 264 ([M+1]+, 100).

Quelle