Reaktion #4471

Reaktionsgleichung

product

6-Fluoro-1,2,3,9-tetrahydro-4H-carbazol-4-one

potassium carbonate

dimethylsulphate

→

title compound

Ausbeute 97.5%

6-Fluoro-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one

Ausbeute 97.5%

Lösungsmittel

acetone

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe mixture was concentrated to one half of its volume
2. 2
   FiltrationThe mixture was filtered off
3. 3
   Waschenwashed with water (50 ml)
4. 4
   Sonstigeair-dried for 1 h
5. 5
   Trocknendried in vacuo over phosphorus pentoxide

Vorschrift

The product of Stage (ii) (7.28 g), potassium carbonate (9.90 g), acetone (70 ml), and dimethylsulphate (5.1 ml) were vigorously stirred at room temperature overnight under nitrogen. The mixture was concentrated to one half of its volume and then stirred with water (350 ml) for 30 min. The mixture was filtered off, washed with water (50 ml), air-dried for 1 h, and dried in vacuo over phosphorus pentoxide to give the title compound as needles (7.59 g), m.p. 157.5°-158.5°.

Quelle