Reaktion #44697

Reaktionsgleichung

2,6-difluorobenzonitrile

potassium carbonate

3-chloro-4-hydroxyaniline

→

2-(4-Amino-2-chlorophenoxy)-6-fluorobenzonitrile

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture is heated
2. 2
   Temperaturat reflux for 45 min
3. 3
   FiltrationThe mixture is filtered
4. 4
   Waschenthe filtercake is washed with ethyl acetate and DCM
5. 5
   SonstigeThe solvent is removed under reduced pressure

Vorschrift

1.00 g (7.19 mmol) of 2,6-difluorobenzonitrile is initially charged in 10 ml of acetonitrile. 1.99 g (14.4 mmol) of potassium carbonate and 1.03 g (7.19 mmol) of 3-chloro-4-hydroxyaniline are added, and the mixture is heated at reflux for 45 min. The mixture is filtered and the filtercake is washed with ethyl acetate and DCM. The solvent is removed under reduced pressure and the residue is by column chromatography (silica gel 60, gradient column: mobile phase: DCM:petroleum ether=2:1, then DCM).

Quelle