Reaktion #44694

Reaktionsgleichung

4-nitro-1H-pyrrolo[2,3-b]pyridine 7-oxide

hexamethyldisilazane

methyl chloroformate

→

6-Chloro-4-nitro-1H-pyrrolo[2,3-b]pyridine

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction solution is filtered through a silica gel cartridge
2. 2
   Waschenis then washed with DCM/methanol 10:1

Vorschrift

Under an atmosphere of argon, 5.00 g (27.9 mmol) of 4-nitro-1H-pyrrolo[2,3-b]pyridine 7-oxide (from example XVI) and 11.8 ml (55.8 mmol) of hexamethyldisilazane are initially charged in 290 ml of THF. At room temperature, 10.8 ml (139.6 mmol) of methyl chloroformate are added. The solution is stirred at RT overnight. The reaction solution is filtered through a silica gel cartridge, and is then washed with DCM/methanol 10:1.

Quelle