Reaktion #446899

Reaktionsgleichung

2-(4-mercaptophenyl)-3-(4-pyridyl)-6,7-dihydro-[5H]-pyrrolo[1,2-a]imidazole

triethylamine

bromomethyl methyl ether

→

desired titled compound

2-(4-Methoxymethylthiophenyl]3-(4-pyridyl) 6,7-dihydro[5H]pyrrolo[1,2-a]imidazole

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturTo an ice bath cooled solution
2. 2
   workup.ADDITIONcontaining

Vorschrift

To an ice bath cooled solution containing 1.0 q (3.4mmole) of 2-(4-mercaptophenyl)-3-(4-pyridyl)-6,7-dihydro-[5H]-pyrrolo[1,2-a]imidazole prepared as in Example 16 and 0.5 ml (3.6 mmole) of triethylamine in 10ml of methylene chloride is added 0.27 ml (3.5 mmole) of bromomethyl methyl ether. The reaction is allowed to warm to room temperature and stirred at room temperature for several hours. Workup and chromatography in a manner analogous to that outlined in example 18 affords the desired titled compound.

Quelle