Reaktion #446345

Reaktionsgleichung

ethyl 3,3-dimethyl-4-pentenoate

3-phenoxybenzyl alcohol

sodium ethoxide

→

3-phenoxybenzyl 3,3-dimethyl-4-pentenoate

Ausbeute 83.9%

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas heated
2. 2
   Temperaturunder reflux for 24 hours, with a Dean-Stark apparatus
3. 3
   workup.ADDITIONcontaining a molecular sieve
4. 4
   Sonstigeto absorb the evolved ethanol
5. 5
   workup.ADDITIONby adding an anhydrous ether solution of hydrogen chloride
6. 6
   workup.ADDITIONThe neutral solution was poured into water
7. 7
   SonstigeThe ether layer was separated
8. 8
   Trocknendried over magnesium sulfate
9. 9
   workup.DISTILLATIONdistilled

Vorschrift

A mixture of 374 mg of ethyl 3,3-dimethyl-4-pentenoate, 400 mg of 3-phenoxybenzyl alcohol and 16 mg of sodium ethoxide in 10 ml of toluene was heated under reflux for 24 hours, with a Dean-Stark apparatus containing a molecular sieve to absorb the evolved ethanol. The mixture was neutralized by adding an anhydrous ether solution of hydrogen chloride. The neutral solution was poured into water. The ether layer was separated, dried over magnesium sulfate, and distilled to give 520 mg (70% yield) of 3-phenoxybenzyl 3,3-dimethyl-4-pentenoate, b.p. 155°-158°/0.3 mm.

Quelle