Reaktion #446287

Reaktionsgleichung

Diethyl 2-ethylmalonate

p-chloroaniline

→

desired product

Ethyl 2-(4-chlorophenylcarbamoyl)butyrate

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturthe mixture was cooled
2. 2
   Waschenfurther, the mixture was washed successively with 1N hydrochloric acid, aqueous sodium bicarbonate solution, and water
3. 3
   Einengenconcentrated under reduced pressure
4. 4
   Wascheneluted with chloroform

Vorschrift

Diethyl 2-ethylmalonate (8.76 ml) and p-chloroaniline (4 g) were dissolved by heating at 130° C. for 11 hours, and the mixture was cooled and dissolved in ethyl acetate, and further, the mixture was washed successively with 1N hydrochloric acid, aqueous sodium bicarbonate solution, and water, and concentrated under reduced pressure. The resulting residue was subjected to column chromatography on silica gel and eluted with chloroform to give the oily desired product (6.66 g).

Quelle