Reaktion #44628

Reaktionsgleichung

methanol

(4R,9aS)-4-(3,4,5-trifluorophenyl)-3,4,7,9a-tetrahydro-1H-pyrido[2,1-c][1,4]oxazin-6-one

→

title compound

Ausbeute 100.1%

(4R,9aS)-4-(3,4,5-trifluorophenyl)hexahydropyrido[2,1-c][1,4]oxazin-6-one

Ausbeute 100.1%

Lösungsmittel

hydrogen

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe resulting reaction solution
2. 2
   Filtrationfiltered through Celite
3. 3
   EinengenThe filtrate was concentrated under reduced pressure

Vorschrift

Platinum oxide (20.1 mg) was added to a methanol solution (6 mL) of (4R,9aS)-4-(3,4,5-trifluorophenyl)-3,4,7,9a-tetrahydro-1H-pyrido[2,1-c][1,4]oxazin-6-one (250 mg). The resulting reaction solution was stirred at room temperature for 2 hr in hydrogen atmosphere and then filtered through Celite. The filtrate was concentrated under reduced pressure to give 252 mg of the title compound. The physical property values of this compound were as follows:

Quelle