Reaktion #44604

Reaktionsgleichung

hydrochloric acid ethyl acetate

[(1R,2R)-2-hydroxy-1-(3,4,5-trifluorophenyl)propyl]carbamic acid tert-butyl ester

→

title compound

(1R,2R)-1-amino-1-(3,4,5-trifluorophenyl)propan-2-ol hydrochloride

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction solution was concentrated under reduced pressure

Vorschrift

A 4 N hydrochloric acid ethyl acetate solution (20 mL) was added to an ethyl acetate solution (50 mL) of [(1R,2R)-2-hydroxy-1-(3,4,5-trifluorophenyl)propyl]carbamic acid tert-butyl ester (4.49 g). This reaction solution was stirred at room temperature for 5 hr. The reaction solution was concentrated under reduced pressure to give 3.5 g of the title compound. The physical property values of this compound were as follows:

Quelle