Reaktion #4459

Reaktionsgleichung

4-fluoro-N-phenoxycarbonylaniline

N-amino-1,2,3,6-tetrahydropyridine hydrochloride

triethylamine

→

N-[[(4-fluorophenyl)carbamoyl]amino]-1,2,3,6-tetrahydropyridine

Ausbeute 45.1%

Lösungsmittel

chloroform

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeAfter evaporation of chloroform
2. 2
   Extraktionthe residue was extracted with ethyl acetate (100 ml)
3. 3
   WaschenThe extract was washed with water
4. 4
   Trocknendried over magnesium sulfate
5. 5
   Sonstigeevaporated in vacuo
6. 6
   SonstigeThe residue was chromatographed on silica gel (20 g)

Vorschrift

A solution of 4-fluoro-N-phenoxycarbonylaniline (2.29 g), N-amino-1,2,3,6-tetrahydropyridine hydrochloride (1.346 g) and triethylamine (1.02 g) in chloroform (25 ml) was refluxed for 20 hours. After evaporation of chloroform, the residue was extracted with ethyl acetate (100 ml). The extract was washed with water, dried over magnesium sulfate and evaporated in vacuo. The residue was chromatographed on silica gel (20 g) using chloroform as an eluent to give N-[[(4-fluorophenyl)carbamoyl]amino]-1,2,3,6-tetrahydropyridine (1.05 g). mp: 156°-157° C.

Quelle