Reaktion #445666

Reaktionsgleichung

6-(α-chloroacetyl)carbostyril

→

6-(α-pyridiniumacetyl)carbostyril chloride

carbostyril

Lösungsmittel

pyridine

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGthe suspension was stirred under ice-
2. 2
   Temperaturcooling for 1 hour
3. 3
   SonstigeThe crystals thus precipitated
4. 4
   Filtrationwere collected by filtration
5. 5
   Sonstigerecrystallized from methanol

Vorschrift

60 Grams of 6-(α-chloroacetyl)carbostyril was suspended in 0.5 kg of pyridine and stirred at 80°-90° C. for 2 hours, then the suspension was stirred under ice-cooling for 1 hour. The crystals thus precipitated were collected by filtration and recrystallized from methanol to obtain 70 g of 6-(α-pyridiniumacetyl)carbostyril chloride 1/2-hydrate in the form of colorless needle-like crystals. Melting point: over 300° C.

Quelle